Details of the Target

General Information of Target

Target ID LDTP08780
Target Name Keratin, type II cytoskeletal 78 (KRT78)
Gene Name KRT78
Gene ID 196374
Synonyms
K5B; KB40; Keratin, type II cytoskeletal 78; Cytokeratin-78; CK-78; Keratin-5b; Keratin-78; K78; Type-II keratin Kb40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGG
RLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNN
QFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGER
GALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVFLSKMELEGKLEALR
EYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEA
EALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDA
EQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGE
ECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIIL
GSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY
Target Bioclass
Other
Family
Intermediate filament family
Uniprot ID
Q8N1N4
Ensemble ID
ENST00000304620.5
HGNC ID
HGNC:28926

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.S444A .
CHL1 SNV: p.L158R .
DU145 SNV: p.T55N .
HCT116 SNV: p.A185T .
ICC12 SNV: p.V129L .
NCIH1299 SNV: p.Q387H .
NCIH2172 SNV: p.S430I .
OCUM1 SNV: p.I336V .
SW1116 SNV: p.S154R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D127(0.99); E133(0.98)  LDD2208  [1]
DBIA
 Probe Info  		C394(1.90); C47(5.51)  LDD3360  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 DM93 C47(1.58)  LDD2472  [2]
 LDCM0023  KB03 A101D C394(1.80); C47(3.52)  LDD2890  [2]
 LDCM0024  KB05 NCI-H3122 C394(1.90); C47(5.51)  LDD3360  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840