Details of the Target

General Information of Target

Target ID LDTP08749
Target Name Centrobin (CNTROB)
Gene Name CNTROB
Gene ID 116840
Synonyms
LIP8; Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS
TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD
PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP
PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA
RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR
LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ
TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD
TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH
HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ
QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW
TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL
TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV
PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH
SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD
GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG
VWR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
Uniprot ID
Q8N137
Ensemble ID
ENST00000380262.7
HGNC ID
HGNC:29616

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R300G .
HEC1B SNV: p.A291V .
HT1376 SNV: p.L285R .
JHH1 SNV: p.T570A .
JURKAT SNV: p.S632N .
MELJUSO SNV: p.P685A .
MEWO SNV: p.P882S .
RL952 SNV: p.P703S; p.P774L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C533(2.40)  LDD3421  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C533(1.75)  LDD2252  [1]
 LDCM0023  KB03 A204 C533(2.18)  LDD2669  [1]
 LDCM0024  KB05 SiSo C533(2.40)  LDD3421  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Teashirt homolog 2 (TSHZ2) Teashirt C2H2-type zinc-finger protein family Q9NRE2
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Elongin-A (ELOA) . Q14241
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
Microspherule protein 1 (MCRS1) . Q96EZ8
Tetratricopeptide repeat protein 23 (TTC23) . Q5W5X9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019