Details of the Target

General Information of Target

Target ID LDTP08747
Target Name Porimin (TMEM123)
Gene Name TMEM123
Gene ID 114908
Synonyms
KCT3; Porimin; Keratinocytes-associated transmembrane protein 3; KCT-3; Pro-oncosis receptor inducing membrane injury; Transmembrane protein 123
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLGARGAWAALLLGTLQVLALLGAAHESAAMAASANIENSGLPHNSSANSTETLQHVPS
DHTNETSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTS
VSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVL
SILYIGCKMYYSRRGIRYRTIDEHDAII
Target Bioclass
Other
Family
CD164 family
Subcellular location
Membrane
Function Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
Uniprot ID
Q8N131
Ensemble ID
ENST00000361236.7
HGNC ID
HGNC:30138

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.M107V .
HCC1143 SNV: p.M189T .
MELJUSO SNV: p.W9R; p.A10T .
NALM6 SNV: p.V135I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor ISY1 homolog (ISY1) ISY1 family Q9ULR0
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Melanoma-associated antigen 11 (MAGEA11) . P43364
Spermatogenesis-associated protein 17 (SPATA17) . Q96L03
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.