Details of the Target

General Information of Target

Target ID LDTP08709
Target Name Palmitoyltransferase ZDHHC14 (ZDHHC14)
Gene Name ZDHHC14
Gene ID 79683
Synonyms
Palmitoyltransferase ZDHHC14; EC 2.3.1.225; DHHC domain-containing cysteine-rich protein 14; DHHC-14; NEW1 domain-containing protein; NEW1CP; Zinc finger DHHC domain-containing protein 14
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPPGGGGPMKDCEYSQISTHSSSPMESPHKKKKIAARRKWEVFPGRNKFFCNGRIMMARQ
TGVFYLTLVLILVTSGLFFAFDCPYLAVKITPAIPAVAGILFFFVMGTLLRTSFSDPGVL
PRATPDEAADLERQIDIANGTSSGGYRPPPRTKEVIINGQTVKLKYCFTCKIFRPPRASH
CSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIFAFVITHVILRSQQTG
FLNALKDSPASVLEAVVCFFSVWSIVGLSGFHTYLISSNQTTNEDIKGSWSNKRGKENYN
PYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSNGITMYGATQSQSDMCDQD
QCIQSTKFVLQAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAE
ATLADVMPRKDEHMGHQFLTPDEAPSPPRLLAAGSPLAHSRTMHVLGLASQDSLHEDSVR
GLVKLSSV
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family, ERF2/ZDHHC9 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling. May play a role in cell differentiation and apoptosis.
Uniprot ID
Q8IZN3
Ensemble ID
ENST00000359775.10
HGNC ID
HGNC:20341

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.R449GfsTer35 .
IPC298 SNV: p.A226V .
Ishikawa (Heraklio) 02 ER Deletion: p.Y211IfsTer10; p.R449GfsTer35 .
JURKAT SNV: p.G140S .
LNCaP clone FGC SNV: p.A373T .
NCIH1703 SNV: p.G454C .
NCIN87 SNV: p.A444V .
NUGC3 Deletion: p.Y211IfsTer10 .
SNGM Deletion: p.Y211IfsTer10 .
SUPT1 SNV: p.P24H .
TE11 SNV: p.S380R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C195(0.93)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C195(0.93)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C195(0.91)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C195(0.84)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402