Details of the Target

General Information of Target

Target ID LDTP08663
Target Name Cilia- and flagella-associated protein 206 (CFAP206)
Gene Name CFAP206
Gene ID 154313
Synonyms
C6orf165; Cilia- and flagella-associated protein 206
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPTQAESVIRSIIREIGQECAAHGEIVSETLIAFMVKAVVLDPSNGFNMDRTLMKSDVQ
NLVKLCMTRLLDTKNPSLDTIKMQVYFDMNYTNRVEFLEEHHRVLESRLGSVTREITDNR
ACAKEELESLYRKIISYVLLRSGLGSPTDIKTVREVTAALQSVFPQAELGTFLTLSKKDK
ERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAVLHVAIPATMQHIDYQLETARSQVYRY
TAILEKAANDPLMRAELQPYMLKEALYNIRQYEVFLQIILSDIITGAQEVEMMTKQLGAH
LEQLKMTIKSKIAVPTSQVFPIFIALSTLWTSLQDETIVVGVLSNLFTHIQPFLGAHELY
FPERVMQCHLNGATVKTDVCRMKEHMEDRVNVADFRKLEWLFPETTANFDKLLIQYRGFC
AYTFAATDGLLLPGNPAIGILKYKEKYYTFNSKDAAYSFAENPEHYIDIVREKAKKNTEL
IQLLELHQQFETFIPYSQMRDADKHYIKPITKCESSTQTNTHILPPTIVRSYEWNEWELR
RKAIKLANLRQKVTHSVQTDLSHLRRENCSQVYPPKDTSTQSMREDSTGVPRPQIYLAGL
RGGKSEITDEVKVNLTRDVDET
Target Bioclass
Other
Family
CFAP206 family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Uniprot ID
Q8IYR0
Ensemble ID
ENST00000369562.9
HGNC ID
HGNC:21405

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0174  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 8 (PSMC5) AAA ATPase family P62195
Methylthioribulose-1-phosphate dehydratase (APIP) Aldolase class II family Q96GX9
Cytokine-like nuclear factor N-PAC (GLYR1) HIBADH-related family Q49A26
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Rho-associated protein kinase 1 (ROCK1) AGC Ser/Thr protein kinase family Q13464
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein CDX-2 (CDX2) Caudal homeobox family Q99626
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 511 (ZNF511) Krueppel C2H2-type zinc-finger protein family Q8NB15
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Golgin-45 (BLZF1) . Q9H2G9
Transcription factor 12 (TCF12) . Q99081
Transcription factor SOX-30 (SOX30) . O94993
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tektin-1 (TEKT1) Tektin family Q969V4
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
Genetic suppressor element 1 (GSE1) . Q14687
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Properdin (CFP) . P27918
Protein hinderin (KIAA1328) . Q86T90
Sterile alpha motif domain-containing protein 3 (SAMD3) . Q8N6K7
UBX domain-containing protein 11 (UBXN11) . Q5T124
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Vinexin (SORBS3) . O60504

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060