Details of the Target

General Information of Target

Target ID LDTP08656
Target Name Synaptotagmin-like protein 1 (SYTL1)
Gene Name SYTL1
Gene ID 84958
Synonyms
SLP1; Synaptotagmin-like protein 1; Exophilin-7; Protein JFC1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEE
GRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGH
DREAEAAVKEKEEGPEPRLTIDEAPQERLRETEGPDFPSPSVPLKASDPEEASQAQEDPG
QGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSS
SVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRR
SDPYVKSYLLPDKQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGR
NIFLGEVEVPLDTWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPP
SGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD
GFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQAL
LEQPCEWVDGLLPLRTNLAPRT
Target Bioclass
Other
Subcellular location
Cell membrane
Function May play a role in vesicle trafficking. Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes.
Uniprot ID
Q8IYJ3
Ensemble ID
ENST00000318074.9
HGNC ID
HGNC:15584

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.S239R .
ETK1 SNV: p.T28N .
HT SNV: p.A281S .
LNCaP clone FGC SNV: p.W83Ter .
MOLT4 SNV: p.P484S; p.Q489Ter; p.Q538Ter .
OVTOKO SNV: p.G509D .
REC1 SNV: p.A214T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C448(1.92); C290(3.11)  LDD3314  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C290(3.46)  LDD2252  [1]
 LDCM0023  KB03 A204 C290(6.35)  LDD2669  [1]
 LDCM0024  KB05 IGR37 C448(1.92); C290(3.11)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264