Details of the Target

General Information of Target

Target ID LDTP08644
Target Name Coiled-coil domain-containing protein 146 (CCDC146)
Gene Name CCDC146
Gene ID 57639
Synonyms
KIAA1505; Coiled-coil domain-containing protein 146
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLP
GTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEV
SKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRE
STEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQ
IGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRAL
LEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERD
FRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNL
AQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQ
QKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVN
EIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKE
KKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINI
QEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQC
TDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQ
VSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKE
VREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPN
GVYTTAEQRPNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Uniprot ID
Q8IYE0
Ensemble ID
ENST00000285871.5
HGNC ID
HGNC:29296

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L185S; p.V588M .
HT SNV: p.K934N .
JURKAT SNV: p.K469E .
JURLMK1 SNV: p.P952L .
LNCaP clone FGC SNV: p.L823I .
MCC13 SNV: p.L743F .
MEWO SNV: p.E856K .
MFE319 Deletion: p.I260LfsTer10 .
MIAPACA2 SNV: p.S272F .
PEO1 SNV: p.Q103R .
SW1990 SNV: p.K432Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		N.A.  LDD0236  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 10B (PSMC6) AAA ATPase family P62333
E3 ubiquitin-protein ligase BRE1B (RNF40) BRE1 family O75150
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C) . Q969Q6
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
THO complex subunit 7 homolog (THOC7) THOC7 family Q6I9Y2
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
Other
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) BLOC1S2 family Q6QNY1
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Cep170-like protein (CEP170P1) CEP170 family Q96L14
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Dysbindin (DTNBP1) Dysbindin family Q96EV8
Geminin (GMNN) Geminin family O75496
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Inhibitory synaptic factor 1 (INSYN1) INSYN1 family Q2T9L4
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 24 (KRT24) Intermediate filament family Q2M2I5
Keratin, type I cytoskeletal 26 (KRT26) Intermediate filament family Q7Z3Y9
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Colorectal mutant cancer protein (MCC) MCC family P23508
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NEDD4-binding protein 3 (N4BP3) N4BP3 family O15049
Nucleosome assembly protein 1-like 2 (NAP1L2) Nucleosome assembly protein (NAP) family Q9ULW6
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7
Alpha-taxilin (TXLNA) Taxilin family P40222
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
GRAM domain-containing protein 4 (GRAMD4) . Q6IC98
Heat shock factor 2-binding protein (HSF2BP) . O75031
Melanoma-associated antigen 11 (MAGEA11) . P43364
Melanoma-associated antigen 6 (MAGEA6) . P43360
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Ninein-like protein (NINL) . Q9Y2I6
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Proline and serine-rich protein 3 (PROSER3) . Q2NL68
SH3 domain-binding protein 1 (SH3BP1) . Q9Y3L3
TNF receptor-associated factor 1 (TRAF1) . Q13077
Uncharacterized protein CCDC197 (CCDC197) . Q8NCU1

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.