Details of the Target

General Information of Target

Target ID LDTP08607
Target Name N-acetylaspartylglutamate synthase A (RIMKLA)
Gene Name RIMKLA
Gene ID 284716
Synonyms
FAM80A; N-acetylaspartylglutamate synthase A; NAAG synthetase A; NAAGS; EC 6.3.2.41; N-acetylaspartylglutamylglutamate synthase A; EC 6.3.2.42; Ribosomal protein S6 modification-like protein A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSQLWFLTDRRIREDYPQVQILRALRQRCSEQDVRFRAVLMDQIAVTIVGGHLGLQLNQ
KALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAG
HGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDICHLI
RHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVKCPLTEQ
GKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGGIIADYTM
SLLPNRQTGKMAVLPGLSSPREKNEPDGCASAQGVAESVYTINSGSTSSESEPELGEIRD
SSASTMGAPPSMLPEPGYNINNRIASELKLK
Target Bioclass
Enzyme
Family
RimK family
Subcellular location
Cytoplasm
Function Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate.
Uniprot ID
Q8IXN7
Ensemble ID
ENST00000431473.4
HGNC ID
HGNC:28725

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C108(25.79)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C235(1.10)  LDD1509  [2]
 LDCM0278  AC19 HEK-293T C235(1.19)  LDD1517  [2]
 LDCM0287  AC27 HEK-293T C235(0.85)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C235(1.09)  LDD1529  [2]
 LDCM0296  AC35 HEK-293T C235(0.84)  LDD1535  [2]
 LDCM0305  AC43 HEK-293T C235(0.98)  LDD1544  [2]
 LDCM0314  AC51 HEK-293T C235(0.99)  LDD1553  [2]
 LDCM0322  AC59 HEK-293T C235(0.98)  LDD1561  [2]
 LDCM0406  CL19 HEK-293T C235(1.23)  LDD1610  [2]
 LDCM0420  CL31 HEK-293T C235(1.10)  LDD1624  [2]
 LDCM0433  CL43 HEK-293T C235(0.99)  LDD1637  [2]
 LDCM0446  CL55 HEK-293T C235(1.22)  LDD1649  [2]
 LDCM0459  CL67 HEK-293T C235(0.94)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C235(1.06)  LDD1665  [2]
 LDCM0472  CL79 HEK-293T C235(1.09)  LDD1675  [2]
 LDCM0486  CL91 HEK-293T C235(1.07)  LDD1689  [2]
 LDCM0022  KB02 BRX142 C235(2.79)  LDD2267  [3]
 LDCM0023  KB03 Jurkat C108(25.79)  LDD0209  [1]
 LDCM0024  KB05 RPMI-8226 C235(1.99)  LDD3411  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840