Details of the Target
General Information of Target
| Target ID | LDTP08605 | |||||
|---|---|---|---|---|---|---|
| Target Name | Large ribosomal subunit protein mL41 (MRPL41) | |||||
| Gene Name | MRPL41 | |||||
| Gene ID | 64975 | |||||
| Synonyms |
BMRP; MRPL27; RPML27; Large ribosomal subunit protein mL41; 39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog
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| 3D Structure | ||||||
| Sequence |
MGVLAAAARCLVRGADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEF
VVPDLTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDGTFDPDNLEKYGFE PTQEGKLFQLYPRNFLR |
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| Target Bioclass |
Other
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| Family |
Mitochondrion-specific ribosomal protein mL41 family
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| Subcellular location |
Mitochondrion
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| Function |
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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Probe 1 Probe Info |
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Y131(18.20) | LDD3495 | [1] | |
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DBIA Probe Info |
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C88(1.48) | LDD3311 | [2] | |
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1d-yne Probe Info |
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N.A. | LDD0358 | [3] | |
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NAIA_5 Probe Info |
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N.A. | LDD2224 | [4] | |
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1c-yne Probe Info |
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N.A. | LDD0228 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References