Details of the Target

General Information of Target

Target ID LDTP08603
Target Name Methionine-R-sulfoxide reductase B3 (MSRB3)
Gene Name MSRB3
Gene ID 253827
Synonyms
Methionine-R-sulfoxide reductase B3; MsrB3; EC 1.8.4.12; EC 1.8.4.14
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSGSCRDKKNCKVVFSQQELRKRLTPLQYH
VTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSETKFDSGSGWPSFHDVINSEAITF
TDDFSYGMHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSAALSFTPADSSGTAEGGSG
VASPAQADKAEL
Target Bioclass
Enzyme
Family
MsrB Met sulfoxide reductase family
Subcellular location
Endoplasmic reticulum; Mitochondrion
Function Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
Uniprot ID
Q8IXL7
Ensemble ID
ENST00000308259.10
HGNC ID
HGNC:27375
ChEMBL ID
CHEMBL3509604

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.07  LDD0403  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 14.07  LDD0403  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 4 (PRDM4) Class V-like SAM-binding methyltransferase superfamily Q9UKN5
EEF1A lysine methyltransferase 3 (EEF1AKMT3) METTL21 family Q96AZ1
Protein N-lysine methyltransferase METTL21A (METTL21A) METTL21 family Q8WXB1
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Transcription factor 4 (TCF4) . P15884
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prosaposin receptor GPR37 (GPR37) G-protein coupled receptor 1 family O15354
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Eukaryotic translation initiation factor 6 (EIF6) EIF-6 family P56537
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Fibulin family Q12805
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Progranulin (GRN) Granulin family P28799
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Mediator of RNA polymerase II transcription subunit 12-like protein (MED12L) Mediator complex subunit 12 family Q86YW9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Four and a half LIM domains protein 3 (FHL3) . Q13643
PRKCA-binding protein (PICK1) . Q9NRD5
Puratrophin-1 (PLEKHG4) . Q58EX7
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Superkiller complex protein 8 (SKIC8) . Q9GZS3
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.