Details of the Target
General Information of Target
| Target ID | LDTP08587 | |||||
|---|---|---|---|---|---|---|
| Target Name | Signal peptide, CUB and EGF-like domain-containing protein 3 (SCUBE3) | |||||
| Gene Name | SCUBE3 | |||||
| Gene ID | 222663 | |||||
| Synonyms |
CEGF3; Signal peptide, CUB and EGF-like domain-containing protein 3 |
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| 3D Structure | ||||||
| Sequence |
MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSG
YTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGN GGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGI ACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETC AVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFE CSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDE CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSG KKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIK QRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRAR TPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRL AGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTF QEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGR TLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCS RCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKR KILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKT SEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQ NYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK |
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| Target Bioclass |
Other
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| Subcellular location |
Secreted
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| Function |
Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors. It is required for ligand-induced recruitment of BMP receptors to lipid rafts. Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 22RV1 | SNV: p.K501E | DBIA Probe Info | |||
| DU145 | SNV: p.R293S | DBIA Probe Info | |||
| HCC44 | Deletion: p.H678TfsTer23 | DBIA Probe Info | |||
| HEC1 | Insertion: p.L436FfsTer5 SNV: p.R573Ter |
DBIA Probe Info | |||
| HEC1B | SNV: p.R573Ter | . | |||
| HT115 | SNV: p.V258A | . | |||
| JURKAT | SNV: p.T966I | . | |||
| MOLT4 | SNV: p.C706Y | . | |||
| NCIH196 | SNV: p.K585N | . | |||
| SUPT1 | SNV: p.T96A | DBIA Probe Info | |||
| U87MG | SNV: p.A241S | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C299(2.82) | LDD3310 | [1] | |
Competitor(s) Related to This Target