Details of the Target

General Information of Target

Target ID LDTP08574
Target Name E3 ubiquitin-protein ligase TRIM48 (TRIM48)
Gene Name TRIM48
Gene ID 79097
Synonyms
RNF101; E3 ubiquitin-protein ligase TRIM48; EC 2.3.2.27; RING finger protein 101; Tripartite motif-containing protein 48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRIIVGTLQRTQRNMNSGISQVFQRELTCPICMNYFIDPVTIDCGHSFCRPCFYLNWQ
DIPILTQCFECIKTIQQRNLKTNIRLKKMASLARKASLWLFLSSEEQMCGIHRETKKMFC
EVDRSLLCLLCSSSQEHRYHRHCPAEWAAEEHWEKLLKKMQSLWEKACENQRNLNVETTR
ISHWKAFGDILYRSESVLLHMPQPLNLALRAGPITGLRDRLNQF
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm, cytosol
Function
E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation. This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress. TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity.
Uniprot ID
Q8IWZ4
Ensemble ID
ENST00000417545.5
HGNC ID
HGNC:19021

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C152(3.43)  LDD3434  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A673 C152(1.10)  LDD2261  [1]
 LDCM0023  KB03 SK-N-MC C152(4.32)  LDD3017  [1]
 LDCM0024  KB05 SK-N-MC C152(3.43)  LDD3434  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840