Details of the Target
General Information of Target
| Target ID | LDTP08545 | |||||
|---|---|---|---|---|---|---|
| Target Name | Pulmonary surfactant-associated protein A2 (SFTPA2) | |||||
| Gene Name | SFTPA2 | |||||
| Gene ID | 729238 | |||||
| Synonyms |
COLEC5; PSAP; SFTP1; SFTPA; SFTPA2B; Pulmonary surfactant-associated protein A2; PSP-A; PSPA; SP-A; SP-A2; 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-5 |
|||||
| 3D Structure | ||||||
| Sequence |
MWLCPLALTLILMAASGAACEVKDVCVGSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPM
GPPGETPCPPGNNGLPGAPGVPGERGEKGEAGERGPPGLPAHLDEELQATLHDFRHQILQ TRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKK YNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLY SRLTICEF |
|||||
| Target Bioclass |
Other
|
|||||
| Family |
SFTPA family
|
|||||
| Subcellular location |
Secreted
|
|||||
| Function |
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C170(0.99) | LDD3323 | [1] | |
Competitor(s) Related to This Target