Details of the Target

General Information of Target

Target ID LDTP08537
Target Name Protein NOXP20 (FAM114A1)
Gene Name FAM114A1
Gene ID 92689
Synonyms
NOXP20; Protein NOXP20; Nervous system overexpressed protein 20; Protein FAM114A1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDDAGDTLATGDKAEVTEMPNSDSLPEDAEVHCDSAAVSHEPTPADPRGEGHENAAVQG
AGAAAIGPPVQPQDANALEPPLNGDVTEDTLAECIDSVSLEAEPRSEIPLQEQNYLAVDS
PPSGGGWAGWGSWGKSLLSSASATVGHGLTAVKEKAGATLRIHGVNSGSSEGAQPNTENG
VPEITDAATDQGPAESPPTSPSSASRGMLSAITNVVQNTGKSVLTGGLDALEFIGKKTMN
VLAESDPGFKRTKTLMERTVSLSQMLREAKEKEKQRLAQQLTMERTAHYGMLFDEYQGLS
HLEALEILSNESESKVQSFLASLDGEKLELLKNDLISIKDIFAAKELENEENQEEQGLEE
KGEEFARMLTELLFELHVAATPDKLNKAMKRAHDWVEEDQTVVSVDVAKVSEEETKKEEK
EEKSQDPQEDKKEEKKTKTIEEVYMSSIESLAEVTARCIEQLHKVAELILHGQEEEKPAQ
DQAKVLIKLTTAMCNEVASLSKKFTNSLTTVGSNKKAEVLNPMISSVLLEGCNSTTYIQD
AFQLLLPVLQVSHIQTSCLKAQP
Target Bioclass
Other
Family
FAM114 family
Subcellular location
Cytoplasm
Function May play a role in neuronal cell development.
Uniprot ID
Q8IWE2
Ensemble ID
ENST00000358869.5
HGNC ID
HGNC:25087

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 SNV: p.S205F .
MCC26 SNV: p.G67E .
MEC1 Insertion: p.T437dup .
MEWO SNV: p.S210F DBIA    Probe Info 
NCIH2291 SNV: p.A117S .
SUPT1 SNV: p.G12Ter; p.V223A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K253(1.52)  LDD0274  [2]
STPyne
 Probe Info  		K153(3.28); K155(2.64); K236(4.07); K237(3.10)  LDD0277  [2]
DBIA
 Probe Info  		C34(0.49)  LDD3337  [3]
BTD
 Probe Info  		C494(0.71)  LDD2096  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C494(20.00)  LDD2227  [9]
 LDCM0022  KB02 HEK-293T C34(1.24)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C34(0.92)  LDD1497  [10]
 LDCM0024  KB05 MSTO-211H C34(0.49)  LDD3337  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C494(0.71)  LDD2096  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C494(0.35)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C458(0.79)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C494(0.23)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C494(0.26)  LDD2124  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C494(0.24)  LDD2126  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C458(0.42)  LDD2128  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C458(0.39)  LDD2143  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Ras-related protein Rab-2A (RAB2A) Rab family P61019
Ras-related protein Rab-2B (RAB2B) Rab family Q8WUD1
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402