Details of the Target

General Information of Target

Target ID LDTP08501
Target Name Solute carrier family 41 member 1 (SLC41A1)
Gene Name SLC41A1
Gene ID 254428
Synonyms
Solute carrier family 41 member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGV
REEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVL
DIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNM
ALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVI
IGSRKIGINPDNVATPIAASLGDLITLALLSGISWGLYLELNHWRYIYPLVCAFFVALLP
VWVVLARRSPATREVLYSGWEPVIIAMAISSVGGLILDKTVSDPNFAGMAVFTPVINGVG
GNLVAVQASRISTFLHMNGMPGENSEQAPRRCPSPCTTFFSPDVNSRSARVLFLLVVPGH
LVFLYTISCMQGGHTTLTLIFIIFYMTAALLQVLILLYIADWMVHWMWGRGLDPDNFSIP
YLTALGDLLGTGLLALSFHVLWLIGDRDTDVGD
Target Bioclass
Transporter and channel
Family
SLC41A transporter family
Subcellular location
Cell membrane
Function
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain.
Uniprot ID
Q8IVJ1
Ensemble ID
ENST00000367137.4
HGNC ID
HGNC:19429

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 7 (ELOVL7) ELO family A1L3X0
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Synapse differentiation-inducing gene protein 1 (SYNDIG1) CD225/Dispanin family Q9H7V2
Gap junction alpha-5 protein (GJA5) Connexin family P36382
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Secretory carrier-associated membrane protein 2 (SCAMP2) SCAMP family O15127
Solute carrier family 13 member 4 (SLC13A4) SLC13A/DASS transporter family Q9UKG4
GPCR
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Free fatty acid receptor 3 (FFAR3) G-protein coupled receptor 1 family O14843
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
G-protein coupled receptor 61 (GPR61) G-protein coupled receptor 1 family Q9BZJ8
Probable G-protein coupled receptor 101 (GPR101) G-protein coupled receptor 1 family Q96P66
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Thyrotropin-releasing hormone receptor (TRHR) G-protein coupled receptor 1 family P34981
Trace amine-associated receptor 9 (TAAR9) G-protein coupled receptor 1 family Q96RI9
Vasopressin V2 receptor (AVPR2) G-protein coupled receptor 1 family P30518
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction beta-5 protein (GJB5) Connexin family O95377
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Protein KASH5 (KASH5) . Q8N6L0
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019