Details of the Target

General Information of Target

Target ID LDTP08495
Target Name Sterile alpha motif domain-containing protein 9-like (SAMD9L)
Gene Name SAMD9L
Gene ID 219285
Synonyms
C7orf6; DRIF2; KIAA2005; UEF; Sterile alpha motif domain-containing protein 9-like; SAM domain-containing protein 9-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKQVSLPEMIKDWTKEHVKKWVNEDLKINEQYGQILLSEEVTGLVLQELTEKDLVEMGL
PWGPALLIKRSYNKLNSKSPESDNHDPGQLDNSKPSKTEHQKNPKHTKKEEENSMSSNID
YDPREIRDIKQEESILMKENVLDEVANAKHKKKGKLKPEQLTCMPYPFDQFHDSHRYIEH
YTLQPETGALNLIDPIHEFKALTNTETATEVDIKMKFSNEVFRFASACMNSRTNGTIHFG
VKDKPHGEIVGVKITSKAAFIDHFNVMIKKYFEESEINEAKKCIREPRFVEVLLQNNTPS
DRFVIEVDTIPKHSICNDKYFYIQMQICKDKIWKQNQNLSLFVREGASSRDILANSKQRD
VDFKAFLQNLKSLVASRKEAEEEYGMKAMKKESEGLKLVKLLIGNRDSLDNSYYDWYILV
TNKCHPNQIKHLDFLKEIKWFAVLEFDPESMINGVVKAYKESRVANLHFPNQYEDKTTNM
WEKISTLNLYQQPSWIFCNGRSDLKSETYKPLEPHLWQRERASEVRKLILFLTDENIMTR
GKFLVVFLLLSSVESPGDPLIETFWAFYQALKGMENMLCISVNSHIYQRWKDLLQTRMKM
EDELTNHSISTLNIELVNSTILKLKSVTRSSRRFLPARGSSSVILEKKKEDVLTALEILC
ENECTETDIEKDKSKFLEFKKSKEEHFYRGGKVSWWNFYFSSENYSSDFVKRDSYEKLKD
LIHCWAESPKPIFAKIINLYHHPGCGGTTLAMHVLWDLKKNFRCAVLKNKTTDFAEIAEQ
VINLVTYRAKSHQDYIPVLLLVDDFEEQENVYFLQNAIHSVLAEKDLRYEKTLVIILNCM
RSRNPDESAKLADSIALNYQLSSKEQRAFGAKLKEIEKQHKNCENFYSFMIMKSNFDETY
IENVVRNILKGQDVDSKEAQLISFLALLSSYVTDSTISVSQCEIFLGIIYTSTPWEPESL
EDKMGTYSTLLIKTEVAEYGRYTGVRIIHPLIALYCLKELERSYHLDKCQIALNILEENL
FYDSGIGRDKFQHDVQTLLLTRQRKVYGDETDTLFSPLMEALQNKDIEKVLSAGSRRFPQ
NAFICQALARHFYIKEKDFNTALDWARQAKMKAPKNSYISDTLGQVYKSEIKWWLDGNKN
CRSITVNDLTHLLEAAEKASRAFKESQRQTDSKNYETENWSPQKSQRRYDMYNTACFLGE
IEVGLYTIQILQLTPFFHKENELSKKHMVQFLSGKWTIPPDPRNECYLALSKFTSHLKNL
QSDLKRCFDFFIDYMVLLKMRYTQKEIAEIMLSKKVSRCFRKYTELFCHLDPCLLQSKES
QLLQEENCRKKLEALRADRFAGLLEYLNPNYKDATTMESIVNEYAFLLQQNSKKPMTNEK
QNSILANIILSCLKPNSKLIQPLTTLKKQLREVLQFVGLSHQYPGPYFLACLLFWPENQE
LDQDSKLIEKYVSSLNRSFRGQYKRMCRSKQASTLFYLGKRKGLNSIVHKAKIEQYFDKA
QNTNSLWHSGDVWKKNEVKDLLRRLTGQAEGKLISVEYGTEEKIKIPVISVYSGPLRSGR
NIERVSFYLGFSIEGPLAYDIEVI
Target Bioclass
Other
Subcellular location
Early endosome
Function May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.
Uniprot ID
Q8IVG5
Ensemble ID
ENST00000318238.9
HGNC ID
HGNC:1349

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.L367YfsTer4 .
A549 Deletion: p.Q1495HfsTer31
SNV: p.Q1495L		 .
AGS SNV: p.F1197V .
AN3CA SNV: p.K648R .
CAMA1 SNV: p.M267I .
CCK81 SNV: p.K1374N .
COLO679 SNV: p.Q491R .
CORL88 SNV: p.W756L DBIA    Probe Info 
HCT15 Insertion: p.Q1409TfsTer49
SNV: p.R788M		 .
HT115 SNV: p.F886L; p.E1018D .
Ishikawa (Heraklio) 02 ER Deletion: p.K648RfsTer6 .
KPNYN SNV: p.E513A .
KYSE410 SNV: p.A775S DBIA    Probe Info 
MCC13 SNV: p.S114L; p.P1240S .
MDAMB231 SNV: p.E392D .
MEWO SNV: p.P80S; p.D826N .
MOLT4 SNV: p.S626L .
NCIH196 SNV: p.I949M .
NCIH23 SNV: p.R1336I .
NCIH446 SNV: p.S1172C .
SISO SNV: p.F1092S .
TE8 SNV: p.P731L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C228(3.23); C316(1.99)  LDD3311  [1]
Acrolein
 Probe Info  		H1091(0.00); K1095(0.00)  LDD0222  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H1091(0.00); K1095(0.00)  LDD0222  [2]
 LDCM0022  KB02 42-MG-BA C1246(1.71)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C1246(2.98)  LDD2661  [1]
 LDCM0024  KB05 G361 C228(3.23); C316(1.99)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.