Details of the Target

General Information of Target

Target ID LDTP08486
Target Name Circadian clock protein PASD1 (PASD1)
Gene Name PASD1
Gene ID 139135
Synonyms
Circadian clock protein PASD1; Cancer/testis antigen 63; CT63; OX-TES-1; PAS domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAEN
ISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNSETHIEFCCHLKRGNVEHG
DSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCILRTQL
LQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGHTSMKAVYVEPAAAAAAAAISDD
QIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRAD
PVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQ
PSSPVAYDIISQELELMKKLKEQLEERTWLLHDAIQNQQNALELMMDHLQKQPNTLRHVV
IPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQ
QLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKK
KKLQERKKWQGQMLQKEPEEEQQKQQLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNH
PVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSN
SEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQ
PTYHQVQVSEVGVEGPPDPQAFQGPAAYQPDQMRSAEQTRLMPAEQRDSNKPC
Target Bioclass
Other
Subcellular location
Nucleus
Function
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed.
Uniprot ID
Q8IV76
Ensemble ID
ENST00000370357.5
HGNC ID
HGNC:20686

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.Q502P .
CCK81 SNV: p.L655M .
COLO800 Insertion: p.L148FfsTer76 .
DU145 SNV: p.V341L .
HCT15 SNV: p.Q163H; p.M762I .
IPC298 SNV: p.P98S .
LNCaP clone FGC SNV: p.S668N .
MCC13 SNV: p.P343S .
MDAMB453 SNV: p.M753I .
MEWO Insertion: p.L148FfsTer76 .
MSTO211H SNV: p.Q479H .
NCIH1155 SNV: p.Q687Ter .
NCIH1793 Substitution: p.L597I .
NCIH2286 SNV: p.G353C .
NCIH358 SNV: p.N255I .
NCIH446 SNV: p.R298M .
SAOS2 SNV: p.P571S .
SNU478 SNV: p.P28H .
SW1116 Insertion: p.L148FfsTer76 .
SW403 SNV: p.P609H .
TE11 SNV: p.M753R .
ZR751 SNV: p.E202K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.