Details of the Target
General Information of Target
| Target ID | LDTP08471 | |||||
|---|---|---|---|---|---|---|
| Target Name | Adipocyte enhancer-binding protein 1 (AEBP1) | |||||
| Gene Name | AEBP1 | |||||
| Gene ID | 165 | |||||
| Synonyms |
ACLP; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein |
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| 3D Structure | ||||||
| Sequence |
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPP
EPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKG KEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLE WPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIE REDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPP DYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEK GKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQ TGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSN DSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGC SVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIY AMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDT RIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPY RVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPT QEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYT GGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTF MEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGY TPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQ RRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEE SETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATG QAFPFTTVETYTVNFGDF |
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| Target Bioclass |
Enzyme
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| Family |
Peptidase M14 family
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| Subcellular location |
Secreted; Cytoplasm
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| Function |
[Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.; [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 22RV1 | SNV: p.L1023P | . | |||
| 42MGBA | SNV: p.K143N | . | |||
| CCK81 | SNV: p.L590R | . | |||
| DU145 | SNV: p.W717Ter | . | |||
| EFO27 | Deletion: p.P185HfsTer107 | . | |||
| HKGZCC | SNV: p.Y771N | . | |||
| ICC12 | SNV: p.V744F | . | |||
| IGROV1 | SNV: p.R534H | . | |||
| JURKAT | SNV: p.R984H | . | |||
| LNCaP clone FGC | SNV: p.G477C | . | |||
| LS180 | SNV: p.L1044I | . | |||
| MDST8 | SNV: p.Y311S | . | |||
| MFE319 | SNV: p.P135Q | . | |||
| MOLT4 | SNV: p.Q1019Ter | . | |||
| NALM6 | SNV: p.K107N | DBIA Probe Info | |||
| NCIH1155 | SNV: p.N754T; p.T936I | . | |||
| NCIH1666 | SNV: p.F474L | . | |||
| OPM2 | SNV: p.I817F | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
TH211 Probe Info |
 |
Y733(12.18); Y771(6.16) | LDD0260 | [1] | |
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DBIA Probe Info |
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C385(1.32) | LDD3332 | [2] | |
Competitor(s) Related to This Target
References