Details of the Target

General Information of Target

Target ID LDTP08465
Target Name CREB3 regulatory factor (CREBRF)
Gene Name CREBRF
Gene ID 153222
Synonyms
C5orf41; CREB3 regulatory factor; Luman recruitment factor; LRF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFL
SLEDCKDIENLESFTDVLDNEGALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGL
DDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPSSFPGKKITSR
AAAPVCSSKTLQAEVPLSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKV
KINPVQQSRPLLSQIHTDAAKENTCYCGAVAKRQEKKGMEPLQGHATPALPFKETQELLL
SPLPQEGPGSLAAGESSSLSASTSVSDSSQKKEEHNYSLFVSDNLGEQPTKCSPEEDEED
EEDVDDEDHDEGFGSEHELSENEEEEEEEEDYEDDKDDDISDTFSEPGYENDSVEDLKEV
TSISSRKRGKRRYFWEYSEQLTPSQQERMLRPSEWNRDTLPSNMYQKNGLHHGKYAVKKS
RRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRL
KKKAQYEANKVKLWGLNTEYDNLLFVINSIKQEIVNRVQNPRDERGPNMGQKLEILIKDT
LGLPVAGQTSEFVNQVLEKTAEGNPTGGLVGLRIPTSKV
Target Bioclass
Transcription factor
Family
BZIP family, CREBRF subfamily
Subcellular location
Nucleus
Function
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
Uniprot ID
Q8IUR6
Ensemble ID
ENST00000296953.6
HGNC ID
HGNC:24050

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.G429D .
KP4 SNV: p.S23A; p.T442R .
SNU5 SNV: p.G309E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C231(2.40)  LDD3369  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C107(0.72)  LDD1520  [2]
 LDCM0289  AC29 HEK-293T C107(0.78)  LDD1528  [2]
 LDCM0298  AC37 HEK-293T C107(0.68)  LDD1537  [2]
 LDCM0307  AC45 HEK-293T C107(0.77)  LDD1546  [2]
 LDCM0312  AC5 HEK-293T C107(0.88)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C107(0.88)  LDD1555  [2]
 LDCM0325  AC61 HEK-293T C107(0.82)  LDD1564  [2]
 LDCM0248  AKOS034007472 HEK-293T C107(0.81)  LDD1511  [2]
 LDCM0409  CL21 HEK-293T C107(0.92)  LDD1613  [2]
 LDCM0422  CL33 HEK-293T C107(1.10)  LDD1626  [2]
 LDCM0435  CL45 HEK-293T C107(0.80)  LDD1639  [2]
 LDCM0448  CL57 HEK-293T C107(1.55)  LDD1651  [2]
 LDCM0461  CL69 HEK-293T C107(0.97)  LDD1664  [2]
 LDCM0475  CL81 HEK-293T C107(0.93)  LDD1678  [2]
 LDCM0484  CL9 HEK-293T C107(1.06)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C107(1.01)  LDD1691  [2]
 LDCM0022  KB02 MCAS C231(1.78)  LDD2449  [1]
 LDCM0023  KB03 MCAS C231(2.05)  LDD2866  [1]
 LDCM0024  KB05 OAW-42 C231(2.40)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402