Details of the Target

General Information of Target

Target ID LDTP08453
Target Name Unconventional myosin-XVIIIb (MYO18B)
Gene Name MYO18B
Gene ID 84700
Synonyms
Unconventional myosin-XVIIIb
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAISSRLALWEQKIREEDKSPPPSSPPPLFSVIPGGFIKQLVRGTEKEAKEARQRKQLAV
ASPEREIPEISISQPNSKSSSGTRSGSQQISQDDQSSSPGSSDILGKESEGSRSPDPEQM
TSINGEKAQELGSSATPTKKTVPFKRGVRRGDVLLMVAKLDPDSAKPEKTHPHDAPPCKT
SPPATDTGKEKKGETSRTPCGSQASTEILAPKAEKTRTGGLGDPGQGTVALKKGEEGQSI
VGKGLGTPKTTELKEAEPQGKDRQGTRPQAQGPGEGVRPGKAEKEGAEPTNTVEKGNVSK
DVGSEGKHVRPQIPGRKWGGFLGRRSKWDGPQNKKDKEGVLLSKAEKTGEPQTQMEKTSQ
VQGELGDDLRMGEKAGELRSTTGKAGESWDKKEKMGQPQGKSGNAGEARSQTEKGCEAPK
EVSTMVESPAAPGKGGWPGSRGQEAEEPCSRAGDGAGALETELEGPSQPALEKDAERPRI
RKENQDGPAPQEEGKGGQSRDSDQAPEDRWYEAEKVWLAQKDGFTLATVLKPDEGTADLP
AGRVRLWIDADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKAQLL
HTCTGPDLIVLQPRGPSVPSAGKVPKGRRDGLPAHIGSMAQRAYWALLNQRRDQSIVALG
WSGAGKTTCCEQVLEHLVGMAGSVDGRVSVEKIRATFTVLRAFGSVSMAHSRSATRFSMV
MSLDFNATGRITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAGLDLDLRTELNLHQMA
DSSSFGMGVWSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACK
VGRKQFMRFEWANYAAEALGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSGL
KMTGVDCVEGMASGLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRA
ATFEELCHNYAHERLQLLFYQRTFVSTLQRYQEEGVPVQFDLPDPSPGTTVAVVDQNPSQ
VRLPAGGGAQDARGLFWVLDEEVHVEGSSDSVVLERLCAAFEKKGAGTEGSSALRTCEQP
LQCEIFHQLGWDPVRYDLTGWLHRAKPNLSALDAPQVLHQSKREELRSLFQARAKLPPVC
RAVAGLEGTSQQALQRSRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIH
CLVPNPVVESRSGQESPPPPQPGRDKPGAGGPLALDIPALRVQLAGFHILEALRLHRTGY
ADHMGLTRFRRQFQVLDAPLLKKLMSTSEGIDERKAVEELLETLDLEKKAVAVGHSQVFL
KAGVISRLEKQREKLVSQSIVLFQAACKGFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVK
DWPWWQLLGSLQPLLSATIGTEQLRAKEEELTTLRRKLEKSEKLRNELRQNTDLLESKIA
DLTSDLADERFKGDVACQVLESERAERLQAFREVQELKSKHEQVQKKLGDVNKQLEEAQQ
KIQLNDLERNPTGGADEWQMRFDCAQMENEFLRKRLQQCEERLDSELTARKELEQKLGEL
QSAYDGAKKMAHQLKRKCHHLTCDLEDTCVLLENQQSRNHELEKKQKKFDLQLAQALGES
VFEKGLREKVTQENTSVRWELGQLQQQLKQKEQEASQLKQQVEMLQDHKRELLGSPSLGE
NCVAGLKERLWKLESSALEQQKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQE
EELEDVRQSCQKRLHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGHRDFDVEKRL
RRDLRRTHALLSDVQLLLGTMEDGKTSVSKEELEKVHSQLEQSEAKCEEALKTQKVLTAD
LESMHSELENMTRNKSLVDEQLYRLQFEKADLLKRIDEDQDDLNELMQKHKDLIAQSAAD
IGQIQELQLQLEEAKKEKHKLQEQLQVAQMRIEYLEQSTVDRAIVSRQEAVICDLENKTE
FQKVQIKRFEVLVIRLRDSLIKMGEELSQAATSESQQRESSQYYQRRLEELKADMEELVQ
REAEASRRCMELEKYVEELAAVRQTLQTDLETSIRRIADLQAALEEVASSDSDTESVQTA
VDCGSSGRKEMDNVSILSSQPEGSLQSWLSCTLSLATDTMRTPSRQSATSSRILSPRINE
EAGDTERTQSALALSRARSTNVHSKTSGDKPVSPHFVRRQKYCHFGDGEVLAVQRKSTER
LEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKRAQRGQGSTLGLEDWPTLPI
YQTTGASTLRRGRAGSDEGNLSLRVGAKSPLEIEGAAGGLLRSTSLKCISSDGVGGTTLL
PEKSKTQFSSCESLLESRPSMGRKLSSPTTPRDMLLSPTLRPRRRCLESSVDDAGCPDLG
KEPLVFQNRQFAHLMEEPLGSDPFSWKLPSLDYERKTKVDFDDFLPAIRKPQTPTSLAGS
AKGGQDGSQRSSIHFETEEANRSFLSGIKTILKKSPEPKEDPAHLSDSSSSSGSIVSFKS
ADSIKSRPGIPRLAGDGGERTSPERREPGTGRKDDDVASIMKKYLQK
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Subcellular location
Cytoplasm
Function
May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Uniprot ID
Q8IUG5
Ensemble ID
ENST00000335473.12
HGNC ID
HGNC:18150

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.G220R .
COLO792 SNV: p.D945N .
COLO800 SNV: p.G132S .
DANG SNV: p.G914A .
HCC1143 SNV: p.S2236F .
HCC15 SNV: p.E2547V .
HCC827 SNV: p.K1825R .
HCT116 Deletion: p.E1680KfsTer7 .
HCT15 SNV: p.I90V; p.Y2023H .
HEC1B SNV: p.M1728I .
HT SNV: p.Y1096H .
HT115 SNV: p.D1523N; p.D1777Y .
ICC108 SNV: p.R1521L .
ICC4 Deletion: p.P27LfsTer32 .
IGR1 SNV: p.G1489R; p.R2527Ter .
IPC298 SNV: p.D2556N .
Ishikawa (Heraklio) 02 ER SNV: p.G36D; p.V241M .
JURKAT SNV: p.P2156L .
JVM3 SNV: p.R848W .
K562 SNV: p.E1932A .
KNS81FD SNV: p.K1702E .
KO52 SNV: p.I2329M .
KYSE30 SNV: p.D945N .
KYSE410 SNV: p.S2105N .
KYSE510 SNV: p.G1034D .
MCC13 Insertion: p.S1562KfsTer4 .
MCC26 SNV: p.P2143L .
MEWO SNV: p.L1002F; p.G1027E; p.A1060V; p.G1290E; p.Q1908Ter .
MFE319 SNV: p.A1918V .
MOLM16 SNV: p.H1580R .
MOLT4 SNV: p.E584K .
NCIH1944 SNV: p.F849Y .
NCIH2286 SNV: p.R1450L .
NCIH2291 SNV: p.P1220R; p.G2206R .
NCIH23 SNV: p.E1708K .
NCIH358 SNV: p.Q2126K
Substitution: p.M1264N		 .
NCIH446 SNV: p.Q1131K
Substitution: p.K2401_E2402delinsNTer		 .
RL SNV: p.E862K .
SHP77 Substitution: p.G330F .
SKMEL2 SNV: p.Q332L .
SKMEL3 SNV: p.A175V .
SKMEL30 SNV: p.G280E; p.G1514R; p.D2554N .
SKN SNV: p.R745P .
SNU308 SNV: p.L2270P .
SNU869 SNV: p.G496E .
SW1271 SNV: p.C1786Ter .
T98G SNV: p.L919I .
TE4 SNV: p.R1141L .
TOV21G SNV: p.E285D; p.E1124Ter; p.R1127L .
WM115 SNV: p.S388F .
WM2664 SNV: p.S388F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1368(4.87)  LDD2157  [1]
ONAyne
 Probe Info  		K2489(6.25)  LDD0275  [2]
DBIA
 Probe Info  		C449(1.81); C178(2.69); C839(3.00)  LDD3401  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EoL-1 C178(1.82)  LDD2324  [3]
 LDCM0023  KB03 EoL-1 C178(1.38)  LDD2741  [3]
 LDCM0024  KB05 RD C449(1.81); C178(2.69); C839(3.00)  LDD3401  [3]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840