General Information of Target

Target ID LDTP08429
Target Name Complement C1q-like protein 4 (C1QL4)
Gene Name C1QL4
Gene ID 338761
Synonyms
CTRP11; Complement C1q-like protein 4; C1q and tumor necrosis factor-related protein 11; C1q/TNF-related protein 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLLLVAIPLLVHSSRGPAHYEMLGRCRMVCDPHGPRGPGPDGAPASVPPFPPGAKGEV
GRRGKAGLRGPPGPPGPRGPPGEPGRPGPPGPPGPGPGGVAPAAGYVPRIAFYAGLRRPH
EGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRGGDGTSMWADLMKNGQV
RASAIAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHGGNTNKYSTFSGFIIYPD
Target Bioclass
Other
Subcellular location
Secreted
Function May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process.
Uniprot ID
Q86Z23
Ensemble ID
ENST00000334221.5
HGNC ID
HGNC:31416

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info 
N.A.  LDD0273  [1]
DBIA
 Probe Info 
C32(2.10)  LDD3427  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC1143 C32(1.84)  LDD2336  [2]
 LDCM0023  KB03 HCC1143 C32(3.33)  LDD2753  [2]
 LDCM0024  KB05 SK-MEL-28 C32(2.10)  LDD3427  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840