Details of the Target

General Information of Target

Target ID LDTP08381
Target Name Cell division cycle protein 20 homolog B (CDC20B)
Gene Name CDC20B
Gene ID 166979
Synonyms
Cell division cycle protein 20 homolog B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK
RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS
RKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG
KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS
FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW
DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA
LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG
GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS
RSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWNCY
Target Bioclass
Enzyme
Family
WD repeat CDC20/Fizzy family
Function Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs).
Uniprot ID
Q86Y33
Ensemble ID
ENST00000296733.5
HGNC ID
HGNC:24222

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L184R; p.W474R .
DU145 SNV: p.K60N .
HCC44 Insertion: p.R336AfsTer41 .
HCT15 SNV: p.E18D .
JURKAT SNV: p.A289V .
OPM2 SNV: p.A148E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0227  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0227  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase PLK2 (PLK2) Ser/Thr protein kinase family Q9NYY3
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Glutaredoxin-3 (GLRX3) . O76003
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin-45 (BLZF1) . Q9H2G9
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Gem-associated protein 4 (GEMIN4) . P57678
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Sperm-associated antigen 5 (SPAG5) . Q96R06

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.