Details of the Target

General Information of Target

Target ID LDTP08356
Target Name 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1)
Gene Name HOGA1
Gene ID 112817
Synonyms
C10orf65; DHDPSL; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; EC 4.1.3.16; Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; Protein 569272
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEEN
LHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVE
MTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPV
DAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVC
ALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGG
PCRAPLQELSPAEEEALRMDFTSNGWL
Target Bioclass
Enzyme
Family
DapA family
Subcellular location
Mitochondrion
Function Catalyzes the final step in the metabolic pathway of hydroxyproline.
Uniprot ID
Q86XE5
Ensemble ID
ENST00000370646.9
HGNC ID
HGNC:25155
ChEMBL ID
CHEMBL5996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FUOV1 SNV: p.G299R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C302(1.68)  LDD3399  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 SNU-1079 C302(0.37)  LDD2604  [2]
 LDCM0023  KB03 SNU-1079 C302(0.32)  LDD3021  [2]
 LDCM0024  KB05 RBE C302(1.68)  LDD3399  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
StAR-related lipid transfer protein 7, mitochondrial (STARD7) . Q9NQZ5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliary microtubule associated protein 1A (CIMAP1A) ODF3 family Q96PU9

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840