Details of the Target

General Information of Target

Target ID LDTP08311
Target Name Juxtaposed with another zinc finger protein 1 (JAZF1)
Gene Name JAZF1
Gene ID 221895
Synonyms
TIP27; ZNF802; Juxtaposed with another zinc finger protein 1; TAK1-interacting protein 27; Zinc finger protein 802
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSY
INRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSS
SFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGC
KKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEIIRK
MQQ
Target Bioclass
Other
Subcellular location
Nucleus
Function
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity.
Uniprot ID
Q86VZ6
Ensemble ID
ENST00000283928.10
HGNC ID
HGNC:28917

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.T117I .
LS180 SNV: p.R102C .
OZ Substitution: p.E140_E141delinsDTer .
RH41 Deletion: p.F10del .
RKO SNV: p.H103R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K79(5.88)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270