Details of the Target

General Information of Target

Target ID LDTP08297
Target Name Lebercilin (LCA5)
Gene Name LCA5
Gene ID 167691
Synonyms
C6orf152; Lebercilin; Leber congenital amaurosis 5 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV
HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS
ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE
KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK
ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN
RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE
PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK
QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD
SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG
NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK
KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS
EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR
Target Bioclass
Other
Family
LCA5 family
Subcellular location
Cytoplasm, cytoskeleton
Function Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.
Uniprot ID
Q86VQ0
Ensemble ID
ENST00000369846.9
HGNC ID
HGNC:31923

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		H674(0.00); K678(0.00)  LDD0222  [1]
DBIA
 Probe Info  		C321(3.01); C329(3.01)  LDD0080  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H674(0.00); K678(0.00)  LDD0222  [1]
 LDCM0022  KB02 HCT 116 C321(3.01); C329(3.01)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C321(1.83); C329(1.83)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C321(3.04); C329(3.04)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
Alpha-taxilin (TXLNA) Taxilin family P40222
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.