Details of the Target

General Information of Target

Target ID LDTP08278
Target Name MORC family CW-type zinc finger protein 1 (MORC1)
Gene Name MORC1
Gene ID 27136
Synonyms
MORC; MORC family CW-type zinc finger protein 1; Cancer/testis antigen 33; CT33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDRYPALQRAQLRLDFIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGG
FMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKK
EETMTCVFFSQTFCEEESLSEVVVPMPSWLIRTRESVTDDPQKFAMELSIIYKYSPFKTE
AELMQQFDVIYGKCGTLLVIYNLKLLLNGEPELDVKTDKEDILMAGALEDFPARWSFRAY
TSVLYFNPWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAFKDEVKKAEEAVKIAE
SILKEAQIKVNQCDRTSLSSAKDVLQRALEDVEAKQKNLKEKQRELKTARTLSLFYGVNV
ENRSQAGMFIYSNNRLIKMHEKVGSQLKLKSLLGAGVVGIVNIPLEVMEPSHNKQEFLNV
QEYNHLLKVMGQYLVQYCKDTGINNRNLTLFCNEFGYQNDIDVEKPLNSFQYQRRQAMGI
PFIIQCDLCLKWRVLPSSTNYQEKEFFDIWICANNPNRLENSCHQVECLPSIPLGTMSTI
SPSKNEKEKQLRESVIKYQNRLAEQQPQPQFIPVDEITVTSTCLTSAHKENTKTQKIRLL
GDDLKHESLSSFELSASRRGQKRNIEETDSDVEYISETKIMKKSMEEKMNSQQQRIPVAL
PENVKLAERSQRSQIANITTVWRAQPTEGCLKNAQAASWEMKRKQSLNFVEECKVLTEDE
NTSDSDIILVSDKSNTDVSLKQEKKEIPLLNQEKQELCNDVLAMKRSSSLPSWKSLLNVP
MEDVNLSSGHIARVSVSGSCKVASSPASSQSTPVKETVRKLKSKLREILLYFFPEHQLPS
ELEEPALSCELEQCPEQMNKKLKMCFNQIQNTYMVQYEKKIKRKLQSIIYDSNTRGIHNE
ISLGQCENKRKISEDKLKNLRIKLALLLQKLQLGGPEGDLEQTDTYLEALLKEDNLLFQN
NLNKVTIDARHRLPLEKNEKTSEN
Target Bioclass
Other
Subcellular location
Nucleus
Function Required for spermatogenesis. Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells.
Uniprot ID
Q86VD1
Ensemble ID
ENST00000232603.10
HGNC ID
HGNC:7198

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T118M .
AN3CA Insertion: p.D508Ter .
COLO679 SNV: p.E816K .
DU145 SNV: p.A477T .
HCT116 Deletion: p.K861SfsTer2 .
HT115 SNV: p.S469Y; p.D760Y .
Ishikawa (Heraklio) 02 ER SNV: p.G904W .
JURKAT SNV: p.R85Q .
KMS27 SNV: p.D968A .
LS180 SNV: p.A7V; p.Q336R .
MCC13 SNV: p.P516L .
MFE319 SNV: p.Q959Ter .
MOLT4 SNV: p.L821V .
NCIH196 SNV: p.V429G .
NCIH661 SNV: p.E141D .
NCIH82 SNV: p.I377N .
OVK18 SNV: p.A42V .
RKO SNV: p.S617G .
SHP77 SNV: p.I678F .
SKMEL2 Deletion: p.D68del .
SW1271 SNV: p.M108I; p.R895G .
WM1552C SNV: p.E422D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0447  [1]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.