Details of the Target

General Information of Target

Target ID LDTP08272
Target Name Protein FAM124A (FAM124A)
Gene Name FAM124A
Gene ID 220108
Synonyms
Protein FAM124A
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQP
LQEAIDNVLAWIHPDLPLFRVSERRASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLH
RTLQQPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRY
DNYADSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLE
FRVRDIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQAQRVHKKFPKPGRVHHASEKKR
HSTPLPSTAVPSHTPGSSQQSPLNSPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRS
KSLFCLPTGGPSLASSAEPQWFSNTGAPGHRASEWRHGHLLSIDDLEGAQETDVDTGLRL
SSSDLSVVSAYSAPSRFCSTVETPLPSERCSSHWAAHKDSREGPLPTVSRVTTEASWASL
PFFTKRSSSSSATARAAPPAPSTSTLTDSSPQLPCDTPKVKQTDGDMPPPPGSAGPGDND
MEEFYI
Target Bioclass
Other
Family
FAM124 family
Uniprot ID
Q86V42
Ensemble ID
ENST00000280057.6
HGNC ID
HGNC:26413

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.D228G .
HEC1 SNV: p.P388Q .
HEC1B SNV: p.P388Q .
HEPG2 SNV: p.P251S .
HT115 SNV: p.F150L; p.G168D .
LNCaP clone FGC SNV: p.P126L; p.R188M .
MCC13 SNV: p.H270Y .
MFE296 SNV: p.L445F .
MOLT4 SNV: p.G138S .
NCIH1793 SNV: p.D215Y .
NCIH2052 SNV: p.R80W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C474(2.01)  LDD2337  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC1187 C474(2.01)  LDD2337  [1]
 LDCM0023  KB03 HCC1187 C474(2.43)  LDD2754  [1]
 LDCM0024  KB05 HCC1187 C474(2.93)  LDD3171  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840