Details of the Target

General Information of Target

Target ID LDTP08227
Target Name Tetraspanin-33 (TSPAN33)
Gene Name TSPAN33
Gene ID 340348
Synonyms
PEN; Tetraspanin-33; Tspan-33; Penumbra; hPen; Proerythroblast new membrane
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACL
AVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSD
KARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSR
ERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLG
GVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Cell membrane
Function
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Uniprot ID
Q86UF1
Ensemble ID
ENST00000486685.3
HGNC ID
HGNC:28743

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		C203(0.00); C183(0.00)  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264