Details of the Target

General Information of Target

Target ID LDTP08202
Target Name Probable ATP-dependent RNA helicase DDX53 (DDX53)
Gene Name DDX53
Gene ID 168400
Synonyms
CAGE; Probable ATP-dependent RNA helicase DDX53; EC 3.6.4.13; Cancer-associated gene protein; Cancer/testis antigen 26; CT26; DEAD box protein 53; DEAD box protein CAGE
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHWAPEWKRAEANPRDLGASWDVRGSRGSGWSGPFGHQGPRAAGSREPPLCFKIKNNMV
GVVIGYSGSKIKDLQHSTNTKIQIINGESEAKVRIFGNREMKAKAKAAIETLIRKQESYN
SESSVDNAASQTPIGRNLGRNDIVGEAEPLSNWDRIRAAVVECEKRKWADLPPVKKNFYI
ESKATSCMSEMQVINWRKENFNITCDDLKSGEKRLIPKPTCRFKDAFQQYPDLLKSIIRV
GIVKPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMPGFIHLDSQPISREQRNGPGML
VLTPTRELALHVEAECSKYSYKGLKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQ
MNNSVNLRSITYLVIDEADKMLDMEFEPQIRKILLDVRPDRQTVMTSATWPDTVRQLALS
YLKDPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFVENMSPNDKVIMFVSQKHIA
DDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIKILITTDIVSRGLDLNDVTHVY
NYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRDSKMAGELIKILDRANQSVPEDLVVM
AEQYKLNQQKRHRETRSRKPGQRRKEFYFLS
Target Bioclass
Enzyme
Family
DEAD box helicase family
Subcellular location
Nucleus
Uniprot ID
Q86TM3
Ensemble ID
ENST00000327968.7
HGNC ID
HGNC:20083

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C163(1.23)  LDD2260  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-549 C163(1.23)  LDD2260  [1]
 LDCM0023  KB03 A-549 C163(2.27)  LDD2677  [1]
 LDCM0024  KB05 A-549 C163(0.90)  LDD3094  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840