Details of the Target

General Information of Target

Target ID LDTP08180
Target Name Immunoglobulin-like domain-containing receptor 1 (ILDR1)
Gene Name ILDR1
Gene ID 286676
Synonyms
Immunoglobulin-like domain-containing receptor 1; Angulin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWPKLPAPWLLLCTWLPAGCLSLLVTVQHTERYVTLFASIILKCDYTTSAQLQDVVVTW
RFKSFCKDPIFDYYSASYQAALSLGQDPSNDCNDNQREVRIVAQRRGQNEPVLGVDYRQR
KITIQNRADLVINEVMWWDHGVYYCTIEAPGDTSGDPDKEVKLIVLHWLTVIFIILGALL
LLLLIGVCWCQCCPQYCCCYIRCPCCPAHCCCPEEALARHRYMKQAQALGPQMMGKPLYW
GADRSSQVSSYPMHPLLQRDLSLPSSLPQMPMTQTTNQPPIANGVLEYLEKELRNLNLAQ
PLPPDLKGRFGHPCSMLSSLGSEVVERRIIHLPPLIRDLSSSRRTSDSLHQQWLTPIPSR
PWDLREGRSHHHYPDFHQELQDRGPKSWALERRELDPSWSGRHRSSRLNGSPIHWSDRDS
LSDVPSSSEARWRPSHPPFRSRCQERPRRPSPRESTQRHGRRRRHRSYSPPLPSGLSSWS
SEEDKERQPQSWRAHRRGSHSPHWPEEKPPSYRSLDITPGKNSRKKGSVERRSEKDSSHS
GRSVVI
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, LISCH7 family
Subcellular location
Cytoplasm, cytosol; Cell membrane
Function
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1.; (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity.
Uniprot ID
Q86SU0
Ensemble ID
ENST00000273691.7
HGNC ID
HGNC:28741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G361 SNV: p.D375N .
MEWO SNV: p.G367E .
MFE296 SNV: p.R120H .
NCIH358 SNV: p.A226D .
SAOS2 SNV: p.H465Y .
SKMEL24 SNV: p.P358S .
UACC257 SNV: p.L53I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C443(2.53)  LDD3354  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 COLO-678 C443(1.45)  LDD2304  [1]
 LDCM0023  KB03 COLO-678 C443(1.74)  LDD2721  [1]
 LDCM0024  KB05 NCI-H2122 C443(2.53)  LDD3354  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840