Details of the Target
General Information of Target
| Target ID | LDTP08169 | |||||
|---|---|---|---|---|---|---|
| Target Name | Amphoterin-induced protein 2 (AMIGO2) | |||||
| Gene Name | AMIGO2 | |||||
| Gene ID | 347902 | |||||
| Synonyms |
ALI1; Amphoterin-induced protein 2; AMIGO-2; Alivin-1; Differentially expressed in gastric adenocarcinomas; DEGA |
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| 3D Structure | ||||||
| Sequence |
MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS
KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST |
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| Target Bioclass |
Immunoglobulin
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| Family |
Immunoglobulin superfamily, AMIGO family
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| Subcellular location |
Cell membrane
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| Function |
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C121(2.75) | LDD3319 | [1] | |
Competitor(s) Related to This Target