Details of the Target

General Information of Target

Target ID LDTP08165
Target Name Ankyrin repeat domain-containing protein 23 (ANKRD23)
Gene Name ANKRD23
Gene ID 200539
Synonyms
DARP; Ankyrin repeat domain-containing protein 23; Diabetes-related ankyrin repeat protein; Muscle ankyrin repeat protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLE
RFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAA
ENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTP
VFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQD
KEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAH
PRTRC
Target Bioclass
Other
Subcellular location
Nucleus
Function May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.
Uniprot ID
Q86SG2
Ensemble ID
ENST00000318357.9
HGNC ID
HGNC:24470

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.D141Y .
CCK81 SNV: p.S211G .
HCT15 SNV: p.L112M .
Ishikawa (Heraklio) 02 ER Deletion: p.H88QfsTer8 .
NCIH1792 Deletion: p.A168PfsTer69 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine--tRNA ligase, cytoplasmic (YARS1) Class-I aminoacyl-tRNA synthetase family P54577
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.