Details of the Target
General Information of Target
| Target ID | LDTP08162 | |||||
|---|---|---|---|---|---|---|
| Target Name | Nucleoplasmin-2 (NPM2) | |||||
| Gene Name | NPM2 | |||||
| Gene ID | 10361 | |||||
| Synonyms |
Nucleoplasmin-2 |
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| 3D Structure | ||||||
| Sequence |
MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH
RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK |
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| Target Bioclass |
Other
|
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| Family |
Nucleoplasmin family
|
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| Subcellular location |
Nucleus
|
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| Function | Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C50(1.62) | LDD2243 | [1] | |
Competitor(s) Related to This Target