Details of the Target

General Information of Target

Target ID LDTP08161
Target Name RNA-binding Raly-like protein (RALYL)
Gene Name RALYL
Gene ID 138046
Synonyms
HNRPCL3; RNA-binding Raly-like protein; hRALYL; Heterogeneous nuclear ribonucleoprotein C-like 3; hnRNP core protein C-like 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGKTQTSNVTNKNDPKSINSRVFIGNLNTAIVKKVDIEAIFSKYGKIVGCSVHKGYAFV
QYMSERHARAAVAGENARVIAGQPLDINMAGEPKPYRPKPGNKRPLSALYRLESKEPFLS
VGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSR
STASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEESLV
LIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK
Target Bioclass
Other
Family
RRM HNRPC family, RALY subfamily
Uniprot ID
Q86SE5
Ensemble ID
ENST00000517638.5
HGNC ID
HGNC:27036

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.E195Ter .
HCT15 SNV: p.K209E .
J82 SNV: p.T204I .
MCC13 SNV: p.G101E .
MEWO SNV: p.Q234H .
NCIH23 SNV: p.L235Ter .
PC9 SNV: p.E195K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C51(1.65)  LDD1699  [1]
DBIA
 Probe Info  		C64(2.75)  LDD3323  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [6]
Crotonaldehyde
 Probe Info  		C51(0.00); H54(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa C51(0.00); H54(0.00)  LDD0222  [6]
 LDCM0107  IAA HeLa C51(0.00); H54(0.00)  LDD0221  [6]
 LDCM0022  KB02 A-375 C64(1.82)  LDD2255  [2]
 LDCM0023  KB03 A-375 C64(2.36)  LDD2672  [2]
 LDCM0024  KB05 SKMEL24 C64(2.75)  LDD3323  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C51(0.18)  LDD2116  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) RRM HNRPC family O60812
Heterogeneous nuclear ribonucleoprotein C-like 2 (HNRNPCL2) RRM HNRPC family B2RXH8
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
RNA-binding Raly-like protein (RALYL) RRM HNRPC family Q86SE5
Tigger transposable element-derived protein 3 (TIGD3) Tigger transposable element derived protein family Q6B0B8
RNA-binding protein 41 (RBM41) . Q96IZ5

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.