Details of the Target

General Information of Target

Target ID LDTP08158
Target Name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (B3GNT8)
Gene Name B3GNT8
Gene ID 374907
Synonyms
B3GALT7; BGALT15; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8; BGnT-8; Beta-1,3-Gn-T8; Beta-1,3-N-acetylglucosaminyltransferase 8; Beta3Gn-T8; EC 2.4.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRCPKCLLCLSALLTLLGLKVYIEWTSESRLSKAYPSPRGTPPSPTPANPEPTLPANLST
RLGQTIPLPFAYWNQQQWRLGSLPSGDSTETGGCQAWGAAAATEIPDFASYPKDLRRFLL
SAACRSFPQWLPGGGGSQVSSCSDTDVPYLLLAVKSEPGRFAERQAVRETWGSPAPGIRL
LFLLGSPVGEAGPDLDSLVAWESRRYSDLLLWDFLDVPFNQTLKDLLLLAWLGRHCPTVS
FVLRAQDDAFVHTPALLAHLRALPPASARSLYLGEVFTQAMPLRKPGGPFYVPESFFEGG
YPAYASGGGYVIAGRLAPWLLRAAARVAPFPFEDVYTGLCIRALGLVPQAHPGFLTAWPA
DRTADHCAFRNLLLVRPLGPQASIRLWKQLQDPRLQC
Target Bioclass
Enzyme
Family
Glycosyltransferase 31 family
Subcellular location
Golgi apparatus membrane
Function
Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.
Uniprot ID
Q7Z7M8
Ensemble ID
ENST00000321702.2
HGNC ID
HGNC:24139

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [1]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) Glycosyltransferase 31 family Q9NY97

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.