Details of the Target
General Information of Target
| Target ID | LDTP08122 | |||||
|---|---|---|---|---|---|---|
| Target Name | FYVE, RhoGEF and PH domain-containing protein 2 (FGD2) | |||||
| Gene Name | FGD2 | |||||
| Gene ID | 221472 | |||||
| Synonyms |
ZFYVE4; FYVE, RhoGEF and PH domain-containing protein 2; Zinc finger FYVE domain-containing protein 4 |
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| 3D Structure | ||||||
| Sequence |
MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm, cytoskeleton
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| Function |
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| COLO792 | SNV: p.G98E | DBIA Probe Info | |||
| EOL1 | SNV: p.R587K | . | |||
| G402 | SNV: p.P25L | . | |||
| HCT15 | SNV: p.L80P | . | |||
| HSC4 | SNV: p.A371V | . | |||
| HUCCT1 | SNV: p.M294K | . | |||
| IPC298 | Substitution: p.P143S | DBIA Probe Info | |||
| JHH7 | SNV: p.A515P | . | |||
| MCC13 | Substitution: p.V355M | . | |||
| MFE319 | SNV: p.L297P | . | |||
| NCIH23 | SNV: p.K459N | . | |||
| NCIH358 | SNV: p.Q298E | . | |||
| SKNSH | SNV: p.A412S | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C622(2.53) | LDD3310 | [1] | |
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IA-alkyne Probe Info |
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C89(1.93) | LDD2182 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0625 | F8 | Ramos | C89(1.95) | LDD2187 | [2] |
| LDCM0576 | Fragment14 | Ramos | C89(1.35) | LDD2193 | [2] |
| LDCM0586 | Fragment28 | Ramos | C89(1.14) | LDD2198 | [2] |
| LDCM0566 | Fragment4 | Ramos | C89(1.03) | LDD2184 | [2] |
| LDCM0569 | Fragment7 | Ramos | C89(0.93) | LDD2186 | [2] |
| LDCM0022 | KB02 | Ramos | C89(1.93) | LDD2182 | [2] |
| LDCM0023 | KB03 | Ramos | C89(1.22) | LDD2183 | [2] |
| LDCM0024 | KB05 | COLO792 | C622(2.53) | LDD3310 | [1] |
References