Details of the Target

General Information of Target

Target ID LDTP08113
Target Name B- and T-lymphocyte attenuator (BTLA)
Gene Name BTLA
Gene ID 151888
Synonyms
B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD antigen CD272
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPV
KYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQ
SNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYRLLPLGGLPLLITTCFCLFCCLRR
HQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGS
EVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
TTD ID
T68001
Uniprot ID
Q7Z6A9
DrugMap ID
TTER58P
Ensemble ID
ENST00000334529.10
HGNC ID
HGNC:21087

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.T10I .
EFO27 SNV: p.I285M .
HT115 SNV: p.A6V .
ICC4 SNV: p.W71C .
KYSE30 SNV: p.G224E .
MCC26 SNV: p.S284F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C286(0.72)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C286(2.24)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C286(7.75)  LDD2190  [1]
 LDCM0576  Fragment14 Ramos C286(1.19)  LDD2193  [1]
 LDCM0566  Fragment4 Ramos C286(0.90)  LDD2184  [1]
 LDCM0569  Fragment7 Ramos C286(1.05)  LDD2186  [1]
 LDCM0022  KB02 Ramos C286(0.72)  LDD2182  [1]
 LDCM0023  KB03 Ramos C286(0.80)  LDD2183  [1]
 LDCM0024  KB05 Ramos C286(0.95)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578