Details of the Target

General Information of Target

Target ID LDTP08108
Target Name Sorting nexin-20 (SNX20)
Gene Name SNX20
Gene ID 124460
Synonyms
SLIC1; Sorting nexin-20; Selectin ligand-interactor cytoplasmic 1; SLIC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPEHPGSPGCMGPITQCTARTQQEAPATGPDLPHPGPDGHLDTHSGLSSNSSMTTREL
QQYWQNQKCRWKHVKLLFEIASARIEERKVSKFVVYQIIVIQTGSFDNNKAVLERRYSDF
AKLQKALLKTFREEIEDVEFPRKHLTGNFAEEMICERRRALQEYLGLLYAIRCVRRSREF
LDFLTRPELREAFGCLRAGQYPRALELLLRVLPLQEKLTAHCPAAAVPALCAVLLCHRDL
DRPAEAFAAGERALQRLQAREGHRYYAPLLDAMVRLAYALGKDFVTLQERLEESQLRRPT
PRGITLKELTVREYLH
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Early endosome membrane
Function
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
Uniprot ID
Q7Z614
Ensemble ID
ENST00000300590.7
HGNC ID
HGNC:30390

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R159C .
Ishikawa (Heraklio) 02 ER SNV: p.Y278C .
JURKAT SNV: p.R175H .
PF382 SNV: p.D241N; p.A248V .
SUPT1 SNV: p.R178Q; p.R203H .
SW480 SNV: p.A160T .
SW620 SNV: p.A160T .
TE8 SNV: p.S105I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C195(1.54)  LDD3370  [1]
IA-alkyne
 Probe Info  		C155(15.56)  LDD1709  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 K052 C195(1.82)  LDD2427  [1]
 LDCM0023  KB03 K052 C195(2.87)  LDD2844  [1]
 LDCM0024  KB05 OCI-AML-2 C195(1.54)  LDD3370  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SAM pointed domain-containing Ets transcription factor (SPDEF) ETS family O95238
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Vimentin (VIM) Intermediate filament family P08670
Serpin H1 (SERPINH1) Serpin family P50454
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Kelch-like protein 12 (KLHL12) . Q53G59
Melanoma-associated antigen 11 (MAGEA11) . P43364
P-selectin glycoprotein ligand 1 (SELPLG) . Q14242

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.