Details of the Target

General Information of Target

Target ID LDTP08103
Target Name Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP)
Gene Name APBB1IP
Gene ID 54518
Synonyms
PREL1; RARP1; RIAM; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1; Proline-rich EVH1 ligand 1; PREL-1; Proline-rich protein 73; Rap1-GTP-interacting adapter molecule; RIAM; Retinoic acid-responsive proline-rich protein 1; RARP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALE
DQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATG
ISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVV
KVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENV
VEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLE
ESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFE
NVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYG
KTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVL
QEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKG
TGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPP
PPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQK
KRGNVS
Target Bioclass
Other
Family
MRL family
Subcellular location
Cell membrane
Function Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Uniprot ID
Q7Z5R6
Ensemble ID
ENST00000356785.4
HGNC ID
HGNC:17379

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.N37H .
HCT15 SNV: p.I83N .
HT115 SNV: p.A292V .
ICC137 SNV: p.L170R .
IGR1 SNV: p.W327Ter .
KYSE410 SNV: p.R201Q .
LS180 Deletion: p.A622RfsTer34
SNV: p.G641D		 .
MDAMB468 Insertion: p.P605_P606dup .
MEWO SNV: p.E168K .
MIAPACA2 Insertion: p.P603_P606dup .
MOLT4 SNV: p.A376V IA-alkyne    Probe Info 
NCIH1793 SNV: p.S475F DBIA    Probe Info 
NCIH196 SNV: p.Q151K .
SNGM SNV: p.I593F .
SNU1 SNV: p.R335W .
SNU478 SNV: p.D70Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C381(4.62); C304(1.48)  LDD3333  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C381(0.00); C355(0.00); C304(0.00); C400(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C381(0.00); C355(0.00); C304(0.00); C400(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C381(0.00); C355(0.00); C400(0.00); C401(0.00)  LDD0037  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C381(2.86)  LDD2245  [1]
 LDCM0023  KB03 697 C381(5.67)  LDD2662  [1]
 LDCM0024  KB05 MOLM-13 C381(4.62); C304(1.48)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell leukemia homeobox protein 3 (TLX3) . O43711

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279