Details of the Target
General Information of Target
| Target ID | LDTP08072 | |||||
|---|---|---|---|---|---|---|
| Target Name | Tripartite motif-containing protein 46 (TRIM46) | |||||
| Gene Name | TRIM46 | |||||
| Gene ID | 80128 | |||||
| Synonyms |
TRIFIC; Tripartite motif-containing protein 46; Gene Y protein; GeneY; Tripartite, fibronectin type-III and C-terminal SPRY motif protein |
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| 3D Structure | ||||||
| Sequence |
MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD |
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| Target Bioclass |
Enzyme
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| Family |
TRIM/RBCC family
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| Subcellular location |
Cell projection, axon
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| Function |
Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 22RV1 | SNV: p.G65C | . | |||
| HCT116 | SNV: p.Q315Ter | . | |||
| HCT15 | SNV: p.A132S | . | |||
| IGROV1 | SNV: p.A640V | . | |||
| JURKAT | SNV: p.A298V | . | |||
| LNCaP clone FGC | SNV: p.E311D | . | |||
| LS180 | Deletion: p.P527RfsTer45 | . | |||
| MDAMB453 | SNV: p.F198L | . | |||
| NB1 | SNV: p.C725Y | DBIA Probe Info | |||
| SKMEL2 | Substitution: p.D103N | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C319(2.49) | LDD3340 | [1] | |
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IA-alkyne Probe Info |
 |
N.A. | LDD0036 | [2] | |
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TFBX Probe Info |
 |
N.A. | LDD0148 | [3] | |
Competitor(s) Related to This Target
References