Details of the Target
General Information of Target
| Target ID | LDTP08071 | |||||
|---|---|---|---|---|---|---|
| Target Name | LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) | |||||
| Gene Name | LIMS2 | |||||
| Gene ID | 55679 | |||||
| Synonyms |
PINCH2; LIM and senescent cell antigen-like-containing domain protein 2; LIM-like protein 2; Particularly interesting new Cys-His protein 2; PINCH-2 |
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| 3D Structure | ||||||
| Sequence |
MTGSNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEG
RKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGR HLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAREL KGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKK GLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFD MKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA |
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| Target Bioclass |
Other
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| Subcellular location |
Nucleus
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| Function |
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| HCT116 | Deletion: p.K322del | . | |||
| JURKAT | SNV: p.R27H | . | |||
| MCC13 | SNV: p.Q251Ter | DBIA Probe Info | |||
| MCC26 | SNV: p.S78F | DBIA Probe Info | |||
| SW756 | SNV: p.E57Q | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C362(0.94); C72(1.13) | LDD3310 | [1] | |
Competitor(s) Related to This Target