Details of the Target

General Information of Target

Target ID LDTP08051
Target Name CUB and sushi domain-containing protein 3 (CSMD3)
Gene Name CSMD3
Gene ID 114788
Synonyms
KIAA1894; CUB and sushi domain-containing protein 3; CUB and sushi multiple domains protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKGIRKGESRAKESKPWEPGKRRCAKCGRLDFILMKKMGIKSGFTFWNLVFLLTVSCVKG
FIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLS
LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN
PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA
CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGS
EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEH
NRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLSPHPA
DTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIK
TASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHR
PVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGY
DTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE
KESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFP
CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDG
DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP
INARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFS
APSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSP
LLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGR
RYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS
PGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSD
LPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGI
GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLN
YENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTL
SSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYG
CNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLR
CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNI
VTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYEL
QGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITV
NADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRS
DGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLT
CIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV
FGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITA
KGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCET
VPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQ
VVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGF
HLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW
NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET
IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ
LQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE
ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW
DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPP
VPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANE
LRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNI
QSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYI
ISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTN
GGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSF
ILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCG
ELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIP
ELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGS
PIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPA
NSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGV
PPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPG
TPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTT
ANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPA
NGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS
NGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG
KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRH
GSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHA
NVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPA
LGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSFNASTGRVNATLSNSNMELL
LSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKD
YGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT
QYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLNTVCTMV
Target Bioclass
Other
Family
CSMD family
Subcellular location
Cell membrane
Function Involved in dendrite development.
Uniprot ID
Q7Z407
Ensemble ID
ENST00000297405.10
HGNC ID
HGNC:19291

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.F3640LfsTer61
SNV: p.V370A		 .
A2780 Insertion: p.K3010EfsTer42 .
CAL148 SNV: p.S2736F .
COLO679 SNV: p.D158N; p.E2508K .
COLO792 SNV: p.Q567Ter; p.G1912R; p.P2939S; p.P3320S .
COLO800 SNV: p.N724S .
CORL88 SNV: p.A273P; p.S2471T .
G402 SNV: p.P1143A .
GB1 Deletion: p.Y2905IfsTer44 .
HCC15 SNV: p.Q2982L .
HCC44 SNV: p.T602S .
HCT15 SNV: p.G2879D; p.K3381N .
HDMYZ Deletion: p.Q941_Y946delinsH .
HEC1 SNV: p.A2551V .
HT SNV: p.V924G; p.S2527P .
HT115 SNV: p.P902S; p.F2240V; p.D3175N; p.R3184I; p.S3362Y; p.S3410R .
ICC9 SNV: p.N467K .
IGR1 SNV: p.P231L; p.G1299E; p.P3320S .
IGR37 SNV: p.C2078S .
IGR39 SNV: p.C2078S .
IGROV1 SNV: p.W1056L .
IM95 SNV: p.G3401E .
IPC298 SNV: p.P258S .
J82 SNV: p.W2745C .
JHH7 SNV: p.D2032V .
JURKAT SNV: p.V1979M .
K562 SNV: p.F1516L .
KMRC3 SNV: p.V1784A .
KMS27 SNV: p.P3491T .
KYSE150 SNV: p.P2635S .
L428 SNV: p.I2701M .
LNCaP clone FGC SNV: p.C204Y; p.P1059S; p.P3491H; p.R3551C .
LOXIMVI SNV: p.G414R; p.W3251G .
MCC13 SNV: p.P82S; p.F1153V .
MCC26 SNV: p.E2414K; p.D2860N .
MELJUSO SNV: p.Y2216S .
MEWO SNV: p.S280L;p.G1337E;p.N2495I;p.F2700I;p.G2818R;p.G3246E;p.P3320L;p.G3646R
Substitution: p.E171K;p.P3513L		 .
MFE319 SNV: p.H1054Q; p.C1727R .
MIAPACA2 SNV: p.E2441G; p.M3142I .
MKN45 SNV: p.H1606N .
MOLT4 SNV: p.Y3080H .
NALM6 SNV: p.K450R .
NCIH146 SNV: p.E1692K .
NCIH1666 SNV: p.N1752K .
NCIH1703 SNV: p.R336S; p.G756V; p.Q1106Ter; p.P2518Q .
NCIH1793 SNV: p.S3504P .
NCIH196 SNV: p.G1597C .
NCIH1993 SNV: p.F194L; p.L2392Q; p.S2666Y .
NCIH2170 SNV: p.T3012A .
NCIH2172 SNV: p.L641I; p.E1219D; p.S1683Y; p.Y2835C .
NCIH2286 SNV: p.G2298W .
NCIH23 SNV: p.L2800I .
NCIH358 Deletion: p.F2383LfsTer10
SNV: p.G66C;p.H1988Y		 .
NCIH661 SNV: p.C3114S; p.C3114Ter .
NOMO1 SNV: p.F940L .
OV90 SNV: p.A237G .
OVK18 Deletion: p.F3640LfsTer61
SNV: p.M3425V		 .
PANC0403 SNV: p.I498V; p.P2105R; p.N2142Y .
PF382 SNV: p.V1982A .
RKO SNV: p.P255H; p.N1781K; p.M3142T; p.W3279R .
RPMI8226 SNV: p.T2719N .
SAOS2 SNV: p.A1895T .
SKMEL24 SNV: p.N332S; p.G1039V .
SKMEL30 SNV: p.E1692K .
SKOV3 SNV: p.C1568Y; p.M3537T .
SNU1 Insertion: p.N1053KfsTer12
SNV: p.E3312D		 .
SNU1079 SNV: p.G1370C .
SUIT2 SNV: p.P1434S .
SUPT1 SNV: p.A3657V .
SW1271 SNV: p.D1703Y .
SW403 SNV: p.D421Y .
SW756 SNV: p.G2351C .
TE4 SNV: p.L1234M; p.W1928Ter; p.N1929I; p.T3156K .
TGBC1TKB SNV: p.S663I .
WM1552C Substitution: p.I219_A220delinsMC .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		C574(0.00); C548(0.00)  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264