Details of the Target

General Information of Target

Target ID	LDTP08049
Target Name	Transmembrane channel-like protein 6 (TMC6)
Gene Name	TMC6
Gene ID	11322
Synonyms	EVER1; EVIN1; Transmembrane channel-like protein 6; Epidermodysplasia verruciformis protein 1; Protein LAK-4
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVT GSSQQTLWRPEGTQSTATLRILASMPSRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNF VRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKRSLRE KSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQ FGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCF THTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCITLVY SMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAEWQLRHS PRSVCGRLRQAAVLGLVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVLPLVVG LLNLGAPYLCRVLAALEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRVGVLQGQC WEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIISEKKLKRRRKPEFDIARNVLELIYGQ TLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPA FLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEAAGPRVSWLPWVHRYLME NTFFVFLVSALLLAVIYLNIQVVRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKER EERSRVGTTEEAAAPPALLTDEQDA
Target Bioclass	Transporter and channel
Family	TMC family
Subcellular location	Endoplasmic reticulum membrane
Function	Probable ion channel.
Uniprot ID	Q7Z403
Ensemble ID	ENST00000306591.11
HGNC ID	HGNC:18021

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
CAL51	SNV: p.S87N	.
HT	SNV: p.V503A	.
JURKAT	SNV: p.W710Ter	.
KATOIII	SNV: p.L493V	.
MELHO	SNV: p.G325A	.
MFE319	SNV: p.R532K	.
MOLT4	SNV: p.V30M	.
NCIH1155	SNV: p.L323P	.
NCIH1666	SNV: p.R744L	.
OCIAML2	SNV: p.G242C	.
TOV21G	SNV: p.Q64K	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IA-alkyne Probe Info			C751(6.29)	LDD1705	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0024	KB05	T cell	C751(6.29)	LDD1705	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Junctophilin-3 (JPH3)				Junctophilin family	Q8WXH2

Transcription factor

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Zinc finger and BTB domain-containing protein 2 (ZBTB2)				.	Q8N680

Immunoglobulin

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1)				.	P16284

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Vimentin (VIM)				Intermediate filament family	P08670

References

1	An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.