Details of the Target
General Information of Target
| Target ID | LDTP08027 | |||||
|---|---|---|---|---|---|---|
| Target Name | Neuronal growth regulator 1 (NEGR1) | |||||
| Gene Name | NEGR1 | |||||
| Gene ID | 257194 | |||||
| Synonyms |
IGLON4; Neuronal growth regulator 1; IgLON family member 4 |
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| 3D Structure | ||||||
| Sequence |
MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRC
YLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSV QTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAK PFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRS GLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAA NKLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ |
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| Target Bioclass |
Immunoglobulin
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| Family |
Immunoglobulin superfamily, IgLON family
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| Subcellular location |
Cell membrane
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| Function | May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
OPA-S-S-alkyne Probe Info |
 |
K231(0.87); K84(1.36); K180(1.72); K52(4.69) | LDD3494 | [1] | |
|
DBIA Probe Info |
 |
C60(1.64) | LDD2260 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transporter and channel
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| NPC intracellular cholesterol transporter 2 (NPC2) | NPC2 family | P61916 | |||
Immunoglobulin
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Limbic system-associated membrane protein (LSAMP) | IgLON family | Q13449 | |||
| Neurotrimin (NTM) | IgLON family | Q9P121 | |||
References