Details of the Target
General Information of Target
| Target ID | LDTP08021 | |||||
|---|---|---|---|---|---|---|
| Target Name | Nik-related protein kinase (NRK) | |||||
| Gene Name | NRK | |||||
| Gene ID | 203447 | |||||
| Synonyms |
Nik-related protein kinase; EC 2.7.11.1 |
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| 3D Structure | ||||||
| Sequence |
MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK
TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN HHSRVYFMTLGKLEELQSNYDV |
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| Target Bioclass |
Enzyme
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| Family |
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
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| Function | May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CCLP1 | SNV: p.L513V | . | |||
| COLO679 | Substitution: p.R1251C | . | |||
| COLO792 | SNV: p.S498F | . | |||
| COLO829 | SNV: p.H1276L | . | |||
| CORL23 | SNV: p.A816S | . | |||
| EFO27 | SNV: p.T1325A; p.S1334P | . | |||
| IGR37 | SNV: p.S101F | . | |||
| IGR39 | SNV: p.S101F | . | |||
| LNCaP clone FGC | SNV: p.E739D | . | |||
| MCC26 | SNV: p.W7Ter; p.Q737Ter | DBIA Probe Info | |||
| MEWO | SNV: p.E889K; p.E898K; p.D1042N | . | |||
| MFE296 | SNV: p.E1575V | . | |||
| MOLT4 | Deletion: p.I782LfsTer66 | . | |||
| NCIH2172 | SNV: p.A836T | . | |||
| NCIH23 | SNV: p.W153Ter | . | |||
| NCIH358 | SNV: p.R1248T | . | |||
| PANC0403 | SNV: p.K1409T | . | |||
| RT112 | SNV: p.F196I | . | |||
| SKMEL28 | SNV: p.G1029R | . | |||
| SNGM | SNV: p.Q961R | . | |||
| SW756 | SNV: p.E783Q | . | |||
| TOV21G | SNV: p.E222Ter; p.R1273L | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C864(2.98) | LDD3358 | [1] | |
Competitor(s) Related to This Target