General Information of Target

Target ID LDTP08020
Target Name PTB-containing, cubilin and LRP1-interacting protein (PID1)
Gene Name PID1
Gene ID 55022
Synonyms
NYGGF4; PCLI1; PTB-containing, cubilin and LRP1-interacting protein; P-CLI1; Phosphotyrosine interaction domain-containing protein 1; Protein NYGGF4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSLPLSLPLCEDTAFLPSKCCSSHKTIKQARTLIMIFLASGTHFQTMLKSKLNVLTLKK
EPLPAVIFHEPEAIELCTTTPLMKTRTHSGCKVTYLGKVSTTGMQFLSGCTEKPVIELWK
KHTLAREDVFPANALLEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIF
AWVYREINDDLSYQMDCHAVECESKLEAKKLAHAMMEAFRKTFHSMKSDGRIHSNSSSEE
VSQELESDDG
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Increases proliferation of preadipocytes without affecting adipocytic differentiation.
Uniprot ID
Q7Z2X4
Ensemble ID
ENST00000354069.6
HGNC ID
HGNC:26084

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C91(2.60)  LDD3404  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CAL-78 C91(1.74)  LDD2291  [1]
 LDCM0023  KB03 42-MG-BA C91(1.67)  LDD2661  [1]
 LDCM0024  KB05 SJRH30 C91(2.60)  LDD3404  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) . Q9HD26
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Dynein axonemal assembly factor 6 (DNAAF6) PIH1 family Q9NQM4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840