Details of the Target

General Information of Target

Target ID LDTP07987
Target Name CXXC-type zinc finger protein 5 (CXXC5)
Gene Name CXXC5
Gene ID 51523
Synonyms
CXXC-type zinc finger protein 5; CF5; Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Retinoid-inducible nuclear factor; RINF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAAAPASVADDTPPPERRN
KSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESADKATAAAAAASLLANGHD
LAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHL
PLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGL
AEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELK
KKPSAALEKVMLPTGAAFRWFQ
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
TTD ID
T91259
Uniprot ID
Q7LFL8
DrugMap ID
TTVS4C3
Ensemble ID
ENST00000302517.8
HGNC ID
HGNC:26943
ChEMBL ID
CHEMBL5169170

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.N274S .
DU145 SNV: p.A186E .
MELJUSO Insertion: p.S95GfsTer17 .
MEWO SNV: p.A109P DBIA    Probe Info 
MOLT4 SNV: p.L145M .
NUGC3 Deletion: p.E57SfsTer40 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C291(1.46)  LDD3310  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C291(1.53)  LDD2254  [1]
 LDCM0023  KB03 A2058 C291(1.93)  LDD2670  [1]
 LDCM0024  KB05 COLO792 C291(1.46)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840