Details of the Target

General Information of Target

Target ID LDTP07956
Target Name Fc receptor-like A (FCRLA)
Gene Name FCRLA
Gene ID 84824
Synonyms
FCRL; FCRL1; FCRLM1; FCRX; FREB; Fc receptor-like A; Fc receptor homolog expressed in B-cells; Fc receptor-like and mucin-like protein 1; Fc receptor-like protein; Fc receptor-related protein X; FcRX
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLGCVLMAWALYLSLGVLWVAQMLLAASFETLQCEGPVCTEESSCHTEDDLTDAREAGF
QVKAYTFSEPFHLIVSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALG
PPGPNREFSITVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSA
EPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIVQSRGLSSEFQIPTASEDHSGSYWC
EAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPGTAPEEAPGPLPPPPTPS
SEDPGFSSPLGMPDPHLYHQMGLLLKHMQDVRVLLGHLLMELRELSGHRKPGTTKATAE
Target Bioclass
Immunoglobulin
Subcellular location
Cytoplasm
Function May be implicated in B-cell differentiation and lymphomagenesis.
Uniprot ID
Q7L513
Ensemble ID
ENST00000236938.12
HGNC ID
HGNC:18504

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DAOY SNV: p.S301A .
DU145 SNV: p.G352W .
HCC827 SNV: p.Q193K .
MCC13 SNV: p.E288K .
NCIH2286 SNV: p.Y210N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C75(1.37)  LDD3403  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C99(1.02)  LDD2245  [1]
 LDCM0023  KB03 A3-KAW C75(2.53)  LDD2674  [1]
 LDCM0024  KB05 Reh C75(1.37)  LDD3403  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840