Details of the Target
General Information of Target
| Target ID | LDTP07939 | |||||
|---|---|---|---|---|---|---|
| Target Name | Synaptic vesicle glycoprotein 2B (SV2B) | |||||
| Gene Name | SV2B | |||||
| Gene ID | 9899 | |||||
| Synonyms |
KIAA0735; Synaptic vesicle glycoprotein 2B |
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| 3D Structure | ||||||
| Sequence |
MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVK
AKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALM ADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSM SLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLG IFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPES PRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWY QRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQD EEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFE DVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYL VSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFC GTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLA AASLVGGGLIALRLPETREQVLM |
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| Target Bioclass |
Transporter and channel
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| Family |
Major facilitator superfamily
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| Subcellular location |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
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| Function |
Probably plays a role in the control of regulated secretion in neural and endocrine cells.; (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 22RV1 | Deletion: p.S224LfsTer21 | DBIA Probe Info | |||
| CCK81 | SNV: p.L658I | . | |||
| COLO679 | SNV: p.P412S | . | |||
| HCC44 | Insertion: p.I629HfsTer73 | . | |||
| HCT116 | SNV: p.L640P | . | |||
| IGR37 | SNV: p.D2N | DBIA Probe Info | |||
| IGR39 | SNV: p.D2N | . | |||
| KNS42 | SNV: p.W109G | . | |||
| MCC13 | SNV: p.G632R; p.R678Q | . | |||
| MELJUSO | SNV: p.A284G | . | |||
| MEWO | SNV: p.G52S | . | |||
| NCIH1048 | SNV: p.M180I | DBIA Probe Info | |||
| NCIH1793 | SNV: p.Y423N | . | |||
| NCIH2172 | SNV: p.Y10F | . | |||
| NUGC3 | Deletion: p.G214VfsTer31 | . | |||
| SW1271 | SNV: p.R106S | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C159(1.58) | LDD3341 | [1] | |
Competitor(s) Related to This Target