Details of the Target

General Information of Target

Target ID LDTP07922
Target Name Coiled-coil domain-containing protein 80 (CCDC80)
Gene Name CCDC80
Gene ID 151887
Synonyms
DRO1; URB; Coiled-coil domain-containing protein 80; Down-regulated by oncogenes protein 1; Up-regulated in BRS-3 deficient mouse homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTWRMGPRFTMLLAMWLVCGSEPHPHATIRGSHGGRKVPLVSPDSSRPARFLRHTGRSRG
IERSTLEEPNLQPLQRRRSVPVLRLARPTEPPARSDINGAAVRPEQRPAARGSPREMIRD
EGSSARSRMLRFPSGSSSPNILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELA
ERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKK
TLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGVEGQVVAEGNDGGGG
AGRPSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATT
VTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPSHRPPTTTEVITARRPSVSENLYPPSRK
DQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPGRFRDNRMDRREHGHRDPNV
VPGPPKPAKEKPPKKKAQDKILSNEYEEKYDLSRPTASQLEDELQVGNVPLKKAKESKKH
EKLEKPEKEKKKKMKNENADKLLKSEKQMKKSEKKSKQEKEKSKKKKGGKTEQDGYQKPT
NKHFTQSPKKSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVI
TIFGPVNNSTMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVD
LRVKQYYEVPITMKSVFDLIDTFQSRIKDMEKQKKEGIVCKEDKKQSLENFLSRFRWRRR
LLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVV
EREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRR
QEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY
Target Bioclass
Other
Family
CCDC80 family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Promotes cell adhesion and matrix assembly.
Uniprot ID
Q76M96
Ensemble ID
ENST00000206423.8
HGNC ID
HGNC:30649

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.Q192Ter .
FTC133 SNV: p.L701P .
HCT116 SNV: p.D215N .
HCT15 SNV: p.P949S .
HKGZCC SNV: p.N874K .
HS936T SNV: p.P493L .
HT115 SNV: p.K240N; p.Y863C .
MCC13 SNV: p.E769K .
MM1S SNV: p.E942K .
NALM6 SNV: p.R467C .
NCIH1793 SNV: p.N788D .
NCIH1975 SNV: p.G298Ter .
NCIH2291 Deletion: p.E490RfsTer65 .
REH SNV: p.R779M; p.R811C .
RL952 SNV: p.E287D .
RPMI8226 SNV: p.G122R .
SUPT1 SNV: p.R8C .
SW1271 SNV: p.E823D .
U937 SNV: p.A405S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C771(2.18)  LDD3441  [1]
BTD
 Probe Info  		C760(0.35)  LDD2100  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 C-4-II C771(2.97)  LDD2282  [1]
 LDCM0023  KB03 Ca-Ski C771(4.46)  LDD2713  [1]
 LDCM0024  KB05 SNU-308 C771(2.18)  LDD3441  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C760(0.35)  LDD2100  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853